| 2024 | |
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Vogt M, Schuchardt N, Geissler ME, Bereuter JP, Geissler RB, Glauche I, Gerdes S, Deußen A, Günther L
Scientific competence during medical education - insights from a cross-sectional study at a German Medical School. BMC medical education 24 (2024) 590, DOI Link |
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Weidner J, Glauche I, Manuwald U, Kern I, Reinecke I, Bathelt F, Amin M, Dong F, Rothe U, Kugler J
Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression. JMIR public health and surveillance 10 (2024) e48682, DOI Link |
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Winter S, Götze KS, Hecker JS, Metzeler KH, Guezguez B, Woods K, Medyouf H, Schäffer A, Schmitz M, Wehner R, Glauche I, Roeder I, Rauner M, Hofbauer LC, Platzbecker U
Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche. Leukemia (2024), DOI Link |
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| 2023 | |
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Hoffmann K, Pelz A, Karg E, Gottschalk A, Zerjatke T, Schuster S, Böhme H, Glauche I, Roeder I
Data integration between clinical research and patient care: A framework for context-depending data sharing and in silico predictions. PLOS digital health 2 (2023) e0000140, DOI Link |
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Schoffer O, Schriefer D, Werblow A, Gottschalk A, Peschel P, Liang LA, Karmann A, Klug SJ
Modelling the effect of demographic change and healthcare infrastructure on the patient structure in German hospitals - a longitudinal national study based on official hospital statistics. BMC health services research 23 (2023) 1081, DOI Link |
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Volz C, Zerjatke T, Gottschalk A, Semper S, Suttorp M, Glauche I, Krumbholz M, Metzler M
Continuous therapy response references for BCR::ABL1 monitoring in pediatric chronic myeloid leukemia. Scientific reports 13 (2023) 18199, DOI Link |
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| 2022 | |
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Karg E, Baldow C, Zerjatke T, Clark RE, Roeder I, Fassoni AC, Glauche I
Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation. Frontiers in oncology 12 (2022) 1028871, DOI Link |
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Wagner S, Baldow C, Calabria A, Rudilosso L, Gallina P, Montini E, Cesana D, Glauche I
Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo. Nature communications 13 (2022) 3712, DOI Link |
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Gotzhein F, Aranyossy T, Thielecke L, Sonntag T, Thaden V, Fehse B, Müller I, Glauche I, Cornils K
The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age. International journal of molecular sciences 23 (2022), DOI Link |
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Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift. Life science alliance 5 (2022), DOI Link |
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Kirova DG, Judasova K, Vorhauser J, Zerjatke T, Leung JK, Glauche I, Mansfeld J
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase. Developmental cell 57 (2022) 1712-1727.e9, DOI Link |
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Salmon M, White HE, Zizkova H, Gottschalk A, Motlova E, Cerveira N, Colomer D, Coriu D, Franke GN, Gottardi E, Izzo B, Jurcek T, Lion T, Schäfer V, Venturi C, Vigneri P, Zawada M, Zuna J, Hovorkova L, Koblihova J, Klamova H, Markova MS, Srbova D, Benesova A, Polivkova V, Zackova D, Mayer J, Roeder I, Glauche I, Ernst T, Hochhaus A, Polakova KM, Cross NCP
Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy. Leukemia 36 (2022) 1879-1886, DOI Link |
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| 2021 | |
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Glauche I, Marr C
Mechanistic models of blood cell fate decisions in the era of single-cell data. Current opinion in systems biology 28 (2021) None, DOI Link |
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Hoffmann H, Baldow C, Zerjatke T, Gottschalk A, Wagner S, Karg E, Niehaus S, Roeder I, Glauche I, Scherf N
How to predict relapse in leukemia using time series data: A comparative in silico study. PloS one 16 (2021) e0256585, DOI Link |
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Roeder I, Glauche I
Overlooking the obvious? On the potential of treatment alterations to predict patient-specific therapy response. Experimental hematology 94 (2021) 26-30, DOI Link |
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Wagner S, Thierbach K, Zerjatke T, Glauche I, Roeder I, Scherf N
TraCurate: Efficiently curating cell tracks SoftwareX 13 (2021) 100656, DOI Link |
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| 2020 | |
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Gottschalk A, Glauche I, Cicconi S, Clark RE, Roeder I
Molecular monitoring during dose reduction predicts recurrence after TKI cessation in CML. Blood 135 (2020) 766-769, DOI Link |
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Hoffmann H, Thiede C, Glauche I, Bornhaeuser M, Roeder I
Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: insights from a mathematical modelling approach. Journal of the Royal Society, Interface 17 (2020) 20200091, DOI Link |
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Hoffmann K, Cazemier K, Baldow C, Schuster S, Kheifetz Y, Schirm S, Horn M, Ernst T, Volgmann C, Thiede C, Hochhaus A, Bornhäuser M, Suttorp M, Scholz M, Glauche I, Loeffler M, Roeder I
Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology. BMC medical informatics and decision making 20 (2020) 28, DOI Link |
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Hähnel T, Baldow C, Guilhot J, Guilhot F, Saussele S, Mustjoki S, Jilg S, Jost PJ, Dulucq S, Mahon FX, Roeder I, Fassoni AC, Glauche I
Model-based inference and classification of immunological control mechanisms from TKI cessation and dose reduction in CML patients. Cancer research 80 (2020) 2394-2406, DOI Link |
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Thielecke L, Cornils K, Glauche I
genBaRcode: a comprehensive R-package for genetic barcode analysis Bioinformatics 36 (2020) 2189-2194, DOI Link |
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Klingebiel T, Jürgens H, Glauche I, Gnekow A, Kandels D, Woessmann W, Schneider DT, Suttorp M
Registries and studies in the Society for Pediatric Oncology and Hematology (GPOH) - What contribution do they make to progress? Klinische Padiatrie 232 (2020) 124-135, DOI Link |
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Machova Polakova K, Zizkova H, Zuna J, Motlova E, Hovorkova L, Gottschalk A, Glauche I, Koblihova J, Pecherkova P, Klamova H, Stastna Markova M, Srbova D, Benesova A, Polivkova V, Jurcek T, Zackova D, Mayer J, Ernst T, Mahon FX, Saussele S, Roeder I, Cross NCP, Hochhaus A
Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission. Leukemia 34 (2020) 2113-2124, DOI Link |
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Morcos MNF, Zerjatke T, Glauche I, Munz CM, Ge Y, Petzold A, Reinhardt S, Dahl A, Anstee NS, Bogeska R, Milsom MD, Säwén P, Wan H, Bryder D, Roers A, Gerbaulet A
Continuous mitotic activity of primitive hematopoietic stem cells in adult mice. The Journal of experimental medicine 217 (2020), DOI Link |
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Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin. The Journal of investigative dermatology 140 (2020) 2433-2441.e5, DOI Link |
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| 2019 | |
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Hoffmann H, Thiede C, Glauche I, Kramer M, Röllig C, Ehninger G, Bornhäuser M, Roeder I
The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia Leukemia 33 (2019) 1531-1534, DOI Link |
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Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I
Hematopoietic Stem Cell Dynamics are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach Stem Cells (2019), DOI Link |
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Fassoni AC, Roeder I, Glauche I
To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment Bulletin of Mathematical Biology (2019) 1-51, DOI Link |
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| 2018 | |
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Glauche I, Kuhn M, Baldow C, Schulze P, Rothe T, Liebscher H, Roy A, Wang X, Roeder I
Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison. Scientific Reports 8 (2018) 12330, DOI Link |
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Fassoni AC, Baldow C, Roeder I, Glauche I
Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: A simulation study based on phase 3 trial data Haematologica 103 (2018) 1825-1834, DOI Link |
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Florian C, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai K, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw M, Glauche I, Geiger H
Aging alters the epigenetic asymmetry of HSC division. PLoS Biology 16 (2018), DOI Link |
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Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice Nature Communications 9 (2018) 1898, DOI Link |
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Große J, Hornstein H, Manuwald U, Kugler J, Glauche I, Rothe U
Incidence of Diabetic Ketoacidosis of New-Onset Type 1 Diabetes in Children and Adolescents in Different Countries Correlates with Human Development Index (HDI): An Updated Systematic Review, Meta-Analysis, and Meta-Regression Hormone and Metabolic Research 03 (2018) 209-22, DOI Link |
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Lyne A, Kent D, Laurenti E, Cornils K, Glauche I, Perié L
A track of the clones: new developments in cellular barcoding. Experimental Hematology 68 (2018) 15-20, DOI Link |
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Roh R, Abramowski A, Hiou-Feige H, Cornils C, Rivals R, Zougman Z, Aranyossy A, Thielecke L, Truan Z, Mermod M, Monnier Y, Prassolov V, Glauche I, Nowrouzi A, Abdollahi A, Fehse B, Simon C, Tolstonog G
Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma. Cell Rep 25 (2018) 2208-2222, DOI Link |
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Shemer A, Grozovski J, Tay T, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim J, David E, Chappell-Maor L, Thielecke L, Glass C, Cornils K, Prinz M, Jung S
Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge Nature Communications (2018), DOI Link |
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Suttorp M, Schulze P, Glauche I, Göhring G, von Neuhoff N, Metzler M, Sedlacek P, de Bont E, Balduzzi A, Lausen B, Aleinikova O, Sufliarska S, Henze G, Strauss G, Eggert
A, Kremens B, Groll A, Berthold F, Klein C, Groß-Wieltsch U, Sykora K, Borkhardt A, Kulozik A, Schrappe M, Nowasz C, Krumbholz M, Tauer J, Claviez A, Harbott J, Kreipe H, Schlegelberger B, Thiede C
Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia 32 (2018) 1657-1669, DOI Link |
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| 2017 | |
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Baldow C, Salentin S, Schroeder M, Roeder I, Glauche I
MAGPIE: Simplifying access and execution of computational models in the life sciences PLOS Computational Biology 13 (2017) 1-11, DOI Link |
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Proschmann R, Baldow C, Rothe T, Suttorp M, Thiede C, Tauer JT, Müller MC, Hochhaus A, Roeder I, Glauche I
Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy. Haematologica 102 (2017) e39-e42, DOI Link |
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Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K
Limitations and challenges of genetic barcode quantification Scientific Reports 7 (2017), DOI Link |
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Aranyossy T, Thielecke L, Glauche I, Fehse B, Cornils K
Genetic barcodes facilitate competitive clonal analyses <i>in vivo</i> Hum Gene Ther. (2017) 1-38, DOI Link |
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Chacón-Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA
Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. The EMBO journal 36 (2017) 151-164, DOI Link |
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Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I
Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion Mol Cancer 16:120 (2017) 1-12, DOI Link |
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Lévy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodríguez FJ, Bernadin O, Costa C, Nègre D, Gutierrez-Guerrero A, Vranckx LS, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren JA, Rio P, Gijsbers R, Cosset FL, Verhoeyen E
Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent Blood Advances 1 (2017) 2088-2104, DOI Link |
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| 2016 | |
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Baldow C, Thielecke L, Glauche I
Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia PLoS ONE 11 (2016) e0165129, DOI Link |
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Glauche I, Scholz M, Löffler M, Roeder I
durch simulation zur optimierten therapie - e:Med-Demonstrator-Projekt HaematoOPT erarbeitet Strategien fuer modellbasierte Optimierung haematologischer Therapien systembiologie.de 11 (2016) 78-82 |
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Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I
Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics. Journal of the Royal Society, Interface 13 (2016) 1-10, DOI Link |
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Roeder I, Scholz M, Glauche I
Systemmedizinische Ansätze in Hämatologie und Onkologie Spectrum Onkologie 06 (2016) 50-52 |
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Herrmann J, Hentschel A, Glauche I, Vollmer A, Schlegel KA, Lutz R
Implant survival and patient satisfaction of reduced diameter implants made from a titanium-zirconium alloy: A retrospective cohort study with 550 implants in 311 patients. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 44 (2016) 1940-44, DOI Link |
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| 2015 | |
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Herberg M, Zerjatke T, de Back W, Glauche I, Roeder I
Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies. Cytometry. Part A : the journal of the International Society for Analytical Cytology (2015), DOI Link |
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Gurrea Salas D, Glauche I, Tauer JT, Thiede C, Suttorp M
Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients? Annals of hematology 94 (2015) 1363-71, DOI Link |
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Hentschel A, Herrmann J, Glauche I, Vollmer A, Schlegel KA, Lutz R
Survival and patient satisfaction of short implants during the first 2Â years of function: a retrospective cohort study with 694 implants in 416 patients. Clinical oral implants research (2015), DOI Link |
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Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder I, Schroeder T, Tresch A
Factor graph analysis of live cell imaging data reveals mechanisms of cell fate decisions. Bioinformatics (Oxford, England) (2015), DOI Link |
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Tauer JT, Hofbauer LC, Jung R, Gerdes S, Glauche I, Erben RG, Suttorp M
Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing rats. PloS one 10 (2015) e0131192, DOI Link |
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| 2014 | |
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Glauche I, Baldow Ch, Fröhlich S, Schulze P, Roy A, Subar M, Wang X, Roeder I
Model-Based Characterization of the Molecular Response Dynamics of Tyrosine Kinase Inhibitor (TKI)-Treated CML Patients a Comparison of Imatinib and Dasatinib First-Line Therapy Blood 124 (2014) 4562 |
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Glauche I, Roeder I
in silico hematology Systembiologie.de 42 (2014) 19 |
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Herberg M, Kalkan T, Glauche I, Smith A, Roeder I
A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs. PloS one 9 (2014) e92496, DOI Link |
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Bach E, Zerjatke T, Herklotz M, Scherf N, Niederwieser D, Roeder I, Pompe T, Cross M, Glauche I
Elucidating functional heterogeneity in hematopoietic progenitor cells: a combined experimental and modeling approach. Experimental hematology 42 (2014) 826-37.e1-17, DOI Link |
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Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B
Multiplexing clonality: combining RGB marking and genetic barcoding. Nucleic acids research (2014), DOI Link |
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Tauer JT, Ulmer A, Glauche I, Jung R, Suttorp M
Long-term imatinib treatment does not cause testicular toxicity in male adolescents with chronic myeloid leukemia and in a juvenile rat model. Klinische Pädiatrie 226 (2014) 169-74, DOI Link |
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| 2013 | |
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Gerdes S, Newrzela S, Glauche I, von Laer D, Hansmann ML, Roeder I
Mathematical modeling of oncogenesis control in mature T-cell populations. Frontiers in immunology 4 (2013) 380, DOI Link |
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Glauche I, Bystrykh L, Eaves C, Roeder I
Stem cell clonality - Theoretical concepts, experimental techniques, and clinical challenges. Blood cells, molecules&diseases (2013), DOI Link |
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Scherf N, Ludborzs C, Thierbach K, Glauche I, Roeder I
A Fluid Registration Approach to Cell Tracking Current Medical Imaging Reviews 9 (2013) 102-12 |
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Cornils K, Bartholomae CC, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B
Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or gamma-retroviral LTR vector. Experimental hematology 41 (2013) 28-38.e3, DOI Link |
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Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, Roeder I
Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Blood 121 (2013) 378-84, DOI Link |
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Schmid B, Shah G, Scherf N, Weber M, Thierbach K, Campos CP, Roeder I, Aanstad P, Huisken J
High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics. Nature communications 4 (2013) 2207, DOI Link |
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Ulmer A, Tabea Tauer J, Glauche I, Jung R, Suttorp M
TK Inhibitor Treatment Disrupts Growth Hormone Axis: Clinical Observations in Children with CML and Experimental Data from a Juvenile Animal Model. Klinische Padiatrie 225 (2013) 120-126, DOI Link |
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