| 2024 | |
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Grützmann K, Kraft T, Meinhardt M, Meier F, Westphal D, Seifert M
Network-based analysis of heterogeneous patient-matched brain and extracranial melanoma metastasis pairs reveals three homogeneous subgroups. Computational and structural biotechnology journal 23 (2024) 1036-1050, DOI Link |
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Grützmann K, Salomo K, Krüger A, Lohse-Fischer A, Erdmann K, Seifert M, Baretton G, Aust D, William D, Schröck E, Thomas C, Füssel S
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles. Biology direct 19 (2024) 38, DOI Link |
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Kraft T, Grützmann K, Meinhardt M, Meier F, Westphal D, Seifert M
Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs. Acta neuropathologica communications 12 (2024) 67, DOI Link |
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Broghammer F, Korovina I, Gouda M, Celotti M, van Es J, Lange I, Brunner C, Mircetic J, Coppes RP, Gires O, Dahl A, Seifert M, Cordes N
Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Molecular cancer 23 (2024) 39, DOI Link |
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Korovina I, Elser M, Borodins O, Seifert M, Willers H, Cordes N
β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models. Biomedicine & Pharmacotherapy 171 (2024) 116217, DOI Link |
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Vidovic M, Lapp HS, Weber C, Plitzko L, Seifert M, Steinacker P, Otto M, Hermann A, Günther R
Comparative analysis of neurofilaments and biomarkers of muscular damage in amyotrophic lateral sclerosis. Brain communications 6 (2024) fcae288, DOI Link |
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Xue Z, Zhang Y, Zhao R, Liu X, Grützmann K, Klink B, Zhang X, Wang S, Zhao W, Sun Y, Han M, Wang X, Hu Y, Liu X, Yang N, Qiu C, Li W, Huang B, Li X, Bjerkvig R, Wang J, Zhou W
The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions. Journal of experimental & clinical cancer research : CR 43 (2024) 25, DOI Link |
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| 2023 | |
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Kraft T, Grützmann K, Meinhardt M, Meier F, Westphal D, Seifert M
Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases. Scientific reports 13 (2023) 444, DOI Link |
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Borodins O, Broghammer F, Seifert M, Cordes N
Meta-analysis of expression and the targeting of cell adhesion associated genes in nine cancer types - A one research lab re-evaluation. Computational and structural biotechnology journal 21 (2023) 2824-2836, DOI Link |
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Han Y, Drobisch P, Krüger A, William D, Grützmann K, Böthig L, Polster H, Seifert L, Seifert AM, Distler M, Pecqueux M, Riediger C, Plodeck V, Nebelung H, Weber GF, Pilarsky C, Kahlert U, Hinz U, Roth S, Hackert T, Weitz J, Wong FC, Kahlert C
Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma. Journal of hematology & oncology 16 (2023) 7, DOI Link |
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Westphal D, Meinhardt M, Grützmann K, Schöne L, Steininger J, Neuhaus LT, Wiegel M, Schrimpf D, Aust DE, Schröck E, Baretton GB, Beissert S, Juratli TA, Schackert GG, Gravemeyer J, Becker JC, von Deimling A, Koelsche C, Klink B, Meier F, Schulz A, Muders MH, Seifert M
Identification of Epigenetically Regulated Genes Distinguishing Intracranial from Extracranial Melanoma Metastases. The Journal of investigative dermatology (2023), DOI Link |
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| 2022 | |
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Mikhaylenko N, Wahnschaffe L, Herling M, Roeder I, Seifert M
Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia. PloS one 17 (2022) e0274463, DOI Link |
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Schwarz A, Roeder I, Seifert M
Comparative Gene Expression Analysis Reveals Similarities and Differences of Chronic Myeloid Leukemia Phases. Cancers 14 (2022), DOI Link |
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Seifert M
Computational Cancer Research: Network-based analysis of cancer data disentangles clinically relevant alterations from molecular measurements Habilitation (2022) TU Dresden |
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Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgöz A, Roeder I, Bornhäuser M, Thiede C, Buchholz F
RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Cells 11 (2022), DOI Link |
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Westphal D, Seifert M
Interview with Dana Westphal and Michael Seifert: "Interdisciplinarity is the only way to answer complex questions" - Interdisciplinary junior research alliance is investigating new therapeutic approaches to melanoma brain metastases gesundhyte.de Issue 14 (2022) 73-76 |
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| 2021 | |
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Braun T, Dechow A, Friedrich G, Seifert M, Stachelscheid J, Herling M
Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact Frontiers in Oncology 11 (2021) 775363, DOI Link |
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Westphal D, Seifert M
Interview mit Dana Westphal und Michael Seifert: "komplexe fragestellungen kann man nur durch interdisziplinarität beantworten" - Interdisziplinärer Juniorverbund forscht an neuen Therapieansätzen für Melanom-Hirnmetastasen gesundhyte.de Ausgabe 14 (2021) 73-76 |
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Westphal D, Wehner R, Meier F, Karreman M, Seifert M
e:Med-Juniorverbund: MelBrainSys – Modellbasierte Vorhersage und experimentelle Validierung neuer therapeutischer Interventionen für Melanom-Hirnmetastasen Spitzenforschung in der onkologischen Dermatologie. Innovationen und Auszeichnungen 2021, ALPHA Informations-GmbH (2021) 38-48 |
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| 2020 | |
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Lauber C, Correia N, Trumpp A, Rieger MA, Dolnik A, Bullinger L, Roeder I, Seifert M
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients. Scientific reports 10 (2020) 12761, DOI Link |
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Seifert M, Schackert G, Temme A, Schröck E, Deutsch A, Klink B
Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs. Cancers 12 (2020), DOI Link |
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Becker LL, Dafsari HS, Schallner J, Abdin D, Seifert M, Petit F, Smol T, Bok L, Rodan L, Krapels I, Spranger S, Weschke B, Johnson K, Straub V, Kaindl AM, Di Donato N, von der Hagen M, Cirak S
The clinical-phenotype continuum in DYNC1H1-related disorders-genomic profiling and proposal for a novel classification. Journal of human genetics (2020), DOI Link |
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Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma , Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Science advances 6 (2020), DOI Link |
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Johansson P, Klein-Hitpass L, Budeus B, Kuhn M, Lauber C, Seifert M, Roeder I, Pförtner R, Stuschke M, Dührsen U, Eckstein A, Dürig J, Küppers R
Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing. Cancers 12 (2020), DOI Link |
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| 2019 | |
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Lauber C, Seifert M, Bartenschlager R, Seitz S
Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses Virus Research 260 (2019) 38-48, DOI Link |
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Seifert M, Peitzsch C, Gorodetska I, Börner C, Klink B, Dubrovska A
Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse PLoS computational biology 15 (2019) e1007460, DOI Link |
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Biedermann J, Preussler M, Conde M, Peitzsch M, Richter S, Wiedemuth R, Abou-El-Ardat K, Krüger A, Meinhardt M, Schackert G, Leenders WP, Herold-Mende C, Niclou SP, Bjerkvig R, Eisenhofer G, Temme A, Seifert M, Kunz-Schughart LA, Schröck E, Klink B
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin Cancers 11 (2019), DOI Link |
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Kolbe E, Aleithe S, Rennert C, Spormann L, Ott F, Meierhofer D, Gajowski R, Stöpel C, Hoehme S, Kücken M, Brusch L, Seifert M, von Schoenfels W, Schafmayer C, Brosch M, Hofmann U, Damm G, Seehofer D, Hampe J, Gebhardt R, Matz-Soja M
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Cell reports 29 (2019) 4553-4567.e7, DOI Link |
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Liu Y, Mi Y, Mueller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, Mehnert M, Seifert M, Emmenlauer M, Sorg I, Bezrukov F, Bena FS, Zhou H, Dehio C, Testa G, Saez-Rodriguez J, Antonarakis SE, Hardt WD, Aebersold R
Multi-omic measurements of heterogeneity in HeLa cells across laboratories Nature Biotechnology (2019), DOI Link |
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Zakrzewski F, Gieldon L, Rump A, Seifert M, Grützmann K, Krüger A, Loos S, Zeugner S, Hackmann K, Porrmann J, Wagner J, Kast K, Wimberger P, Baretton G, Schröck E, Aust D, Klink B
Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples BMC Cancer 19 (2019) 396, DOI Link |
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| 2018 | |
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Gladitz J, Klink B, Seifert M
Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion Acta Neuropathologica Communications (2018), DOI Link |
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Lauber C, Klink B, Seifert M
Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups BMC Cancer 18 (2018) 399, DOI Link |
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Klapproth E, Dickreuter E, Zakrzewski F, Seifert M, Petzold A, Dahl A, Schröck E, Klink B, Cordes N
Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition Oncotarget (2018) 1-16, DOI Link |
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Mäder L, Blank AE, Capper D, Jansong J, Baumgarten P, Wirsik NM, Zachskorn C, Ehlers J, Seifert M, Klink B, Liebner S, Niclou S, Naumann U, Harter PN, Mittelbronn M
Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma Oncotarget 9 (2018) 24041-24053, DOI Link |
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| 2017 | |
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Seifert M, Beyer A
regNet: An R package for network-based propagation of gene expression alterations Bioinformatics btx544 (2017) 1-4, DOI Link |
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Abou-El-Ardat K, Seifert M, Becker K, Eisenreich S, Lehmann M, Hackmann K, Rump A, Meijer G, Carvalho B, Temme A, Schackert G, Schröck E, Krex D, Klink B
Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neuro Oncol 19 (2017) 546-57, DOI Link |
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Alfonso JCL, Talkenberger K, Seifert M, Klink B, Hawkins-Daarud A, Swanson KR, Hatzikirou H, Deutsch A
The biology and mathematical modelling of glioma invasion: a review Journal of The Royal Society Interface 14 (2017), DOI Link |
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Buder T, Deutsch A, Seifert M, Voss-Böhme A
CellTrans: An R Package to Quantify Stochastic Cell State Transitions Bioinform Biol Insights 11 (2017) 1-14, DOI Link |
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Vehlow A, Klapproth E, Storch K, Dickreuter E, Seifert M, Dietrich A, Bütof R, Temme A, Cordes N
Adhesion- and stress-related adaptation of glioma radiochemoresistance is circumvented by beta-1 integrin/JNK co-targeting Oncotarget (2017) 1-14, DOI Link |
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| 2016 | |
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Seifert M, Friedrich B, Beyer A
Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis Genome Biology 17 (2016) 1-25, DOI Link |
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| 2015 | |
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Seifert M, Garbe M, Friedrich B, Mittelbronn M, Klink B
Comparative transcriptomics reveals similarities and differences between astrocytoma grades. BMC cancer 15 (2015) 952, DOI Link |
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